RESUMO
This study aimed to investigate the absorption mechanism of three curcumin constituents in rat small intestines. Self-emulsification was used to solubilize the three curcumin constituents, and the rat in situ intestinal perfusion method was used to study factors on drug absorption, including drug mass concentration, absorption site, and the different types and concentrations of absorption inhibitors. Within the scope of experimental concentrations, three curcumin constituents were absorbed in rat small intestines through the active transport mechanism.
Assuntos
Adjuvantes Farmacêuticos/farmacologia , Curcumina/análogos & derivados , Curcumina/farmacocinética , Inibidores Enzimáticos/farmacocinética , Absorção Intestinal , Intestino Delgado/metabolismo , 2,4-Dinitrofenol/farmacocinética , Transportadores de Cassetes de Ligação de ATP/antagonistas & inibidores , Animais , Cromatografia Líquida de Alta Pressão/métodos , Curcumina/química , Diarileptanoides , Emulsões , Feminino , Absorção Intestinal/efeitos dos fármacos , Intestino Delgado/efeitos dos fármacos , Masculino , Proteína 2 Associada à Farmacorresistência Múltipla , Proteínas Associadas à Resistência a Múltiplos Medicamentos/análise , Proteínas Associadas à Resistência a Múltiplos Medicamentos/antagonistas & inibidores , Imagem de Perfusão/métodos , Probenecid/farmacologia , Ratos Sprague-Dawley , Valores de Referência , Reprodutibilidade dos Testes , Fatores de Tempo , Desacopladores/farmacologia , Verapamil/farmacologiaRESUMO
This study aimed to investigate the absorption mechanism of three curcumin constituents in rat small intestines. Self-emulsification was used to solubilize the three curcumin constituents, and the rat in situ intestinal perfusion method was used to study factors on drug absorption, including drug mass concentration, absorption site, and the different types and concentrations of absorption inhibitors. Within the scope of experimental concentrations, three curcumin constituents were absorbed in rat small intestines through the active transport mechanism.
